A cell-permeable

NU 7026 – 5 mg

Brand:
Cayman
CAS:
154447-35-5
Storage:
-20
UN-No:
Non-Hazardous - /

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).{17273} It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase.{17273} NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation.{17273} It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.{17274}  

 

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Description

A cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM); poorly inhibits PI3K (IC50 = 13 µM) and is inactive against ATM, ATR, and PARP-1

Formal name: 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one

Synonyms:  DNA-PK Inhibitor II|LY293646

Molecular weight: 281.3

CAS: 154447-35-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|DNA-PK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|DNA-PK Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Cell Signaling

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