A Cdk2 inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B

NU 6140 – 10 mg

Brand:
Cayman
CAS:
444723-13-1
Storage:
-20
UN-No:
Non-Hazardous - /

NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H.{28149} NU 6140 has been found to induce cell-cycle arrest at the G2-M phase and to potentiate the apoptotic effect of paclitaxel (Item No. 10461) in HeLa cells by inhibiting the anti-apoptotic protein, survivin.{28149}  

 

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Description

A Cdk2 inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H; induces cell-cycle arrest at the G2-M phase

Formal name: 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-benzamide

Synonyms: 

Molecular weight: 422.5

CAS: 444723-13-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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