An inhibitor of PARPs (IC50 = 400 nM); enhances the cytotoxicity of γ-irradiation and certain anticancer drugs; also used to study the regulation of DNA repair by PARP enzymes

NU 1025 – 1 mg

Brand:
Cayman
CAS:
90417-38-2
Storage:
-20
UN-No:
Non-Hazardous - /

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).{23208} It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs.{23204,23205} NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.{23206}  

 

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Description

An inhibitor of PARPs (IC50 = 400 nM); enhances the cytotoxicity of γ-irradiation and certain anticancer drugs; also used to study the regulation of DNA repair by PARP enzymes

Formal name: 8-hydroxy-2-methyl-4(3H)-quinazolinone

Synonyms:  NSC 696807

Molecular weight: 176.2

CAS: 90417-38-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|PARP

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