A selective

NSC 95397 – 10 mg

Brand:
Cayman
CAS:
93718-83-3
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 95397 is a 1,4-naphthoquinone-based irreversible inhibitor of Cdc25 dual-specificity phosphatases, with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively.{33364} It displays >125-fold selectivity for Cdc25 over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. NSC 95397 significantly inhibits the growth of human and murine carcinoma cells, blocking G2/M phase transition.{33364,17981} In rat liver epithelial cells, NSC 95397 induces cell cycle arrest, which is associated with phosphorylation of EGFR, activation of ERK1/2, phosphorylation of connexin43, and downregulation of gap junctional intercellular communication.{33365}  

 

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Description

A selective, irreversible inhibitor of Cdc25 dual-specificity phosphatases, with Ki values of 32, 96, and 40 nM for Cdc25A, Cdc25B, and Cdc25C, respectively; significantly inhibits the growth of human and murine carcinoma cells, blocking G2/M phase transition

Formal name: 2,3-bis[(2-hydroxyethyl)thio]-1,4-naphthalenedione

Synonyms:  Cdc25 Inhibitor IV|PTP Inhibitor XXIX

Molecular weight: 310.4

CAS: 93718-83-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Cycle

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