A selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A

NSC 697923 – 25 mg

Brand:
Cayman
CAS:
343351-67-7
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro.{31222} It also inhibits NF-κB activation by PMA and other agonists, presumably through its effects on Ubc13.{31222} NSC 697923 blocks proliferation and induces apoptosis in diffuse large B cell lymphoma and neuroblastoma cells.{31222,31221} It has antitumor efficacy in vivo in neuroblastoma orthotopic xenografts, when given intraperitoneally.{31221}  

 

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Description

A selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro; blocks proliferation and induces apoptosis in DLBCL and NB cells

Formal name: 2-[(4-methylphenyl)sulfonyl]-5-nitro-furan

Synonyms: 

Molecular weight: 267.3

CAS: 343351-67-7

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Epigenetics, Transcription, & Translation|Writers|Ubiquitination||Research Area|Immunology & Inflammation

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