A potent inhibitor of Mdm2 interaction with p53 by binding Mdm2 (Ki = 120 nM)

NSC 66811 – 5 mg

Brand:
Cayman
CAS:
6964-62-1
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.{31195} NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro. Inhibitors of the Mdm2-p53 interaction, including NSC 66811, induce p53- and p21-dependent cell cycle arrest and p53-dependent cell death in tumor cell lines.{31196}  

 

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Description

A potent inhibitor of Mdm2 interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53

Formal name: 2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol

Synonyms: 

Molecular weight: 340.4

CAS: 6964-62-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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