An inhibitor of the DUBs USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 (EC50s = 45

NSC 632839 – 1 mg

Brand:
Cayman
CAS:
157654-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 µM, respectively.{27604} It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 µM in cells sensitized by E1A, an adenoviral oncogene).{27605}  

 

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Description

An inhibitor of the DUBs USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 (EC50s = 45, 37, and 9.8 µM, respectively); inhibits apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation

Formal name: 3,5-bis[(4-methylphenyl)methylene]-4-piperidinone, monohydrochloride

Synonyms:  F6|Ubiquitin Isopeptidase Inhibitor II

Molecular weight: 339.9

CAS: 157654-67-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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