An inhibitor of WRN helicase (IC50 = 230 nM); inhibits the ATPase

NSC 617145 – 10 mg

Brand:
Cayman
CAS:
203115-63-3
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 617145 is an inhibitor of WRN helicase (IC50 = 230 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.{38654} It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only exhibiting 7% inhibition of RECQ1 at a concentration of 5 µM. NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C (Item No. 11435) to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.  

 

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Description

An inhibitor of WRN helicase (IC50 = 230 nM); inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner; inhibits growth of HeLa cells via formation of DSBs and induction of apoptosis in a WRN helicase-dependent manner

Formal name: 1,1′-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

Synonyms: 

Molecular weight: 400

CAS: 203115-63-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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