NSC 348884 – 5 mg

Brand:
Cayman
CAS:
81624-55-7
Storage:
-20
UN-No:
Non-Hazardous - /

Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis.{27213} NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.{27213,27214}  

 

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Description

A small molecule inhibitor of nucleophosmin dimers that can prevent cell proliferation and induce apoptosis in various cancer cell lines (IC50s = 1.4-4 µM)


Formal name: N1,​N1,​N2,​N2-​tetrakis[(6-​methyl-​1H-​benzimidazol-2-​yl)​methyl]-1,​2-ethanediamine

Synonyms: 

Molecular weight: 636.8

CAS: 81624-55-7

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis