An inhibitor of MDMX; decreases MDMX promoter activity in a reporter assay in a concentration-dependent manner; decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX at 5 µmol/L; induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner at 5 µmol/L; induces p53-independent apoptosis in wild-type

NSC 207895 – 1 mg

Brand:
Cayman
CAS:
58131-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 207895 is an inhibitor of the p53-binding protein MDMX.{48617} It decreases MDMX promoter activity in a reporter assay using HT-1080 cells in a concentration-dependent manner. NSC 207895 (5 µmol/L) decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX. It also increases the expression of the pro-apoptotic genes PUMA, Bax, and PIG3. NSC 207895 (5 µmol/L) induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner. It also induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively).{48617,48618}  

 

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SKU: 27949 - 1 mg Category:

Description

An inhibitor of MDMX; decreases MDMX promoter activity in a reporter assay in a concentration-dependent manner; decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX at 5 µmol/L; induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner at 5 µmol/L; induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively)

Formal name: 4-(4-methyl-1-piperazinyl)-7-nitro-2,1,3-benzoxadiazole, 3-oxide

Synonyms:  NSC 179940|XI-006

Molecular weight: 279.3

CAS: 58131-57-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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