An extracellular trap for FGF2 that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1; inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice

NSC 12 – 10 mg

Brand:
Cayman
CAS:
102586-30-1
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs).{32843} NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes.{32843} NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.{32843}  

 

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SKU: 20117 - Category:

Description

An extracellular trap for FGF2 that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1; inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice

Formal name: (3β)-24,24,24-trifluoro-23-(trifluoromethyl)-21-norchol-5-ene-3,20,23-triol

Synonyms:  NSC 172285

Molecular weight: 484.5

CAS: 102586-30-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Angiogenesis

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