A cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation; blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 µM; suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine

NS3694 – 50 mg

Brand:
Cayman
CAS:
426834-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome.{30930} NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation.{30929} It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 µM.{30929} NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1.{30929} It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine (Item No. 81590).{30929} NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.{30931,28612,30928}  

 

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Description

A cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation; blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 µM; suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine

Formal name: 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzoic acid

Synonyms:  Apoptosis Inhibitor II

Molecular weight: 358.7

CAS: 426834-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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