A nonselective activator of SK/KCa2 and IK/KCa3.1 channels (EC50s range from 0.12-1.2 µM and 10-90 nM for SK and IK channels

NS309 – 50 mg

Brand:
Cayman
CAS:
18711-16-5
Storage:
-20
UN-No:
Non-Hazardous - /

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).{27789,25556} It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels.{27789,25556,27794} NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects.{27789,25556} It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO (Item No. 14575) and often used in conjunction with CyPPA (Item No. 15614) to distinguish between SK1 and SK3 subtypes.{27789,25556}  

 

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Description

A nonselective activator of SK/KCa2 and IK/KCa3.1 channels (EC50s range from 0.12-1.2 µM and 10-90 nM for SK and IK channels, respectively); also activates Kv11.1 channels (hERG; IC50 = 1 µM), but does not affect BK/KCa1.1 channels; modulates neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects

Formal name: 6,​7-​dichloro-1H-​indole-​2,​3-​dione 3-​oxime

Synonyms: 

Molecular weight: 231

CAS: 18711-16-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience

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