A positive allosteric modulator of the α7-containing nAChRs

NS 1738 – 5 mg

Brand:
Cayman
CAS:
501684-93-1
Storage:
-20
UN-No:
Non-Hazardous - /

NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs).{29720} When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 µM).{29720} NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats.{29720} NS 1738 also improves performance in the rat social recognition test.{29720} NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.{33287,33288}  

 

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Description

A positive allosteric modulator of the α7-containing nAChRs, increasing the peak amplitude of the current flowing through α7-containing nAChRs when applied with ACh (EC50 = 3.4 µM); modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats

Formal name: N-(5-chloro-2-hydroxyphenyl)-N’-[2-chloro-5-(trifluoromethyl)phenyl]-urea

Synonyms:  NSC 213859

Molecular weight: 365.1

CAS: 501684-93-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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