A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation; cardioprotective against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models

NS 1619 – 25 mg

Brand:
Cayman
CAS:
153587-01-0
Storage:
-20
UN-No:
Non-Hazardous - /

NS 1619 is a calcium-dependent activator of large-conductance Ca2+-activated K+ (BKCa) channels in vascular smooth muscle.{30652} It is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation.{30656,30653} Studies suggest that activation of BKCa channels by NS 1619 can protect the cardiac muscle against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models.{30655,30654}  

 

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Description

A calcium-dependent activator of BKCa channels that is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation; cardioprotective against pulmonary hypertension as well as ischemia and reperfusion injury in various animal models

Formal name: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

Synonyms: 

Molecular weight: 362.2

CAS: 153587-01-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Vasculature|Smooth Muscle Cells||Research Area|Cardiovascular System|Vasculature|Vasodilation

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