A chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist; has protonophoric activity

NPPB – 50 mg

Brand:
Cayman
CAS:
107254-86-4
Storage:
-20
UN-No:
Non-Hazardous - /

NPPB is a chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist.{28152,23789,28153} It has been shown to activate the GPR35-Gαi/o and GPR35-Gα16 pathways in HEK293 cells, inducing intracellular calcium mobilization.{28153} NPPB has protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.{28154}  

 

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Description

A chloride channel blocker (IC50 = 80 nM) that has also been identified as a GPR35 agonist; has protonophoric activity, uncoupling mitochondrial ATP synthesis in phagocytes

Formal name: 5-nitro-2-[(3-phenylpropyl)amino]-benzoic acid

Synonyms:  HOE 144|Hoechst 144

Molecular weight: 300.3

CAS: 107254-86-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Mitochondrial Biology

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