A selective PKC inhibitor (IC50 = 19 µM); inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases

NPC-15437 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
141774-20-1
Storage:
-20
UN-No:
Non-Hazardous - /

NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 µM).{34103} It competitively inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.{34102}  

 

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SKU: 20212 - Category:

Description

A selective PKC inhibitor (IC50 = 19 µM); inhibits phorbol ester- (Ki = 5 µM) and phosphatidylserine-induced (Ki = 12 µM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases

Formal name: (2S)-2,6-diamino-N-[[1-(1-oxotridecyl)-2-piperidinyl]methyl]-hexanamide, dihydrochloride

Synonyms: 

Molecular weight: 511.6

CAS: 141774-20-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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