A saponin with diverse biological activities; induces proliferation

Notoginsenoside Ft1 – 5 mg

Brand:
Cayman
CAS:
155683-00-4
Storage:
-20
UN-No:
Non-Hazardous - /

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities.{37598,37599,37600,37601,37602} It induces proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) via nuclear translocation of hypoxia-inducible factor-1α (HIF-1α) and activation of the PI3K/AKT and Raf/MEK/ERK signaling pathways in a manner dependent on mammalian target of rapamycin (mTOR).{37598} Notoginsenoside Ft1 (45 μM) induces cell cycle arrest at the S and G2/M phases and promotes apoptosis of SH-SY5Y cells.{37599} It increases cGMP levels and induces relaxation of isolated precontracted rat mesenteric arteries, effects that are reversed by the nitric oxide synthase inhibitor L-NAME (Item No. 80210) and ODQ (Item No. 81410), an inhibitor of soluble guanylyl cyclase.{37600} In vivo, notoginsenoside Ft1 (0.25, 2.5, and 25 mg/kg) promotes angiogenesis and decreases wound diameter in a mouse model of punched-hole ear injury.{37598} Notoginsenoside Ft1 (1.25 mg/kg) decreases tail bleeding time and increases thrombus weight in a rat tail bleeding assay.{37601} Topical administration of notoginsenoside Ft1 increases mRNA expression of the collagen expression, fibroblast proliferation, and scar formation genes COL1A1, COL3A1, TGF-β1, TGF-β3, and fibronectin, promotes neovascularization, reduces monocyte infiltration, and shortens wound closure time in a db/db mouse model of diabetic foot ulcers.{37602}  

 

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SKU: 24976 - 5 mg Category:

Description

A saponin with diverse biological activities; induces proliferation, migration, and tube formation of HUVECs in an mTOR-dependent manner; induces cell cycle arrest at the S and G2/M phases and promotes apoptosis of SH-SY5Y cells at 45 μM; increases cGMP levels and induces relaxation of isolated precontracted rat mesenteric arteries; promotes angiogenesis and decreases wound diameter in a mouse model of punched-hole ear injury at 0.25, 2.5, and 25 mg/kg; decreases tail bleeding time and increases thrombus weight in a rat tail bleeding assay at 1.25 mg/kg; increases mRNA expression of collagen expression, fibroblast proliferation, and scar formation genes; promotes neovascularization, reduces monocyte infiltration, and shortens wound closure time in a db/db mouse model of diabetic foot ulcers

Formal name: (3β,12β,20R)-12,20-dihydroxydammar-24-en-3-yl O-β-D-xylopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside

Synonyms: 

Molecular weight: 917.1

CAS: 155683-00-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Saponins||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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