A PP1 and PP2A inhibitor (IC50s = 9 and 3 µM

Norcantharidin – 1 g

Brand:
Cayman
CAS:
29745-04-8
Storage:
-20
UN-No:
Non-Hazardous - /

Norcantharidin is a demethylated form of the protein phosphatase 1 (PP1) and PP2A inhibitor cantharidin (Item No. 14589) and a PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively).{46995,46996} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines when used at a concentration of 5 µg/ml.{46996} Norcantharidin (500-5,000 µg/ml) reduces angiogenesis in a chick chorioallantoic membrane assay.{46997} It inhibits growth in a panel of nine human cancer cell lines, including breast, lung, skin, and glioblastoma cancer cells, with GI50 values ranging from 30 to 64 µM.{46995} Norcantharidin (28 mg/kg, i.p.) reduces tumor growth in a GBC-SD mouse xenograft model.  

 

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Description

A PP1 and PP2A inhibitor (IC50s = 9 and 3 µM, respectively); induces cell cycle arrest at the G2/M phase and apoptosis in HepG2, Hep3B, and Huh7 human hepatoma cell lines at 5 µg/ml; reduces angiogenesis in a chick chorioallantoic membrane assay at 500-5,000 µg/ml; inhibits growth in a panel of nine human cancer cell lines (GI50s = 30-64 µM); reduces tumor growth in a GBC-SD mouse xenograft model at 28 mg/kg

Formal name: (3aR,4S,7R,7aS)-rel-hexahydro-4,7-epoxyisobenzofuran-1,3-dione

Synonyms:  Demethylcantharidin|NCTD|NSC 59023

Molecular weight: 168.1

CAS: 29745-04-8

Purity: ≥95%

Formulation: A crystalline solid

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