A TRPV1 agonist; toxic to NHBE

Nonivamide – 5 g

Brand:
Cayman
CAS:
2444-46-4
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin (Item Nos. 92350 | 10010743) that has been isolated from Capsicum species.{41887,41890} It is toxic to NHBE, BEAS-2B, and BEAS-2B cells overexpressing TRPV1 (TRPV1-OE; LC50s = 160, 115, and 1 µM, respectively), increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM), and increases GADD153 mRNA expression by 7- and 6-fold when used at concentrations of 2 and 20 µM, respectively.{41890} Nonivamide (1 µM) also increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner.{41888} In mice, it reduces respiration when inhaled and is toxic with LD50 values of 200 and 413 mg/kg for oral and inhaled administration, respectively.{41889} Formulations containing nonivamide have been used in pepper spray weaponry for riot control.  

 

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SKU: 25328 - 5 g Category:

Description

A TRPV1 agonist; toxic to NHBE, BEAS-2B, and TRPV1-OE cells (LC50s = 160, 115, and 1 µM, respectively); increases calcium flux in TRPV1-OE cells (EC50 = 1.4 µM); increases GADD153 mRNA expression by 7- and 6-fold at 2 and 20 µM, respectively; increases the release of dopamine and serotonin from SH-SY5Y cells in a calcium-dependent and TRPV1-independent manner at 1 µM; reduces respiration and is toxic to mice (LD50s = 200 and 413 mg/kg for oral and inhaled administration, respectively)

Formal name: N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide

Synonyms:  Nonanoic Acid Vanillylamide|NSC 172795|N-Vanillylnonanamide|N-Vanillylpelargonamide|Pelargonic Acid Vanillylamide|Pseudocapsaicin

Molecular weight: 293.4

CAS: 2444-46-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience

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