Description
An anthracycline antitumor antibiotic; intercalates with DNA; inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 μM, respectively); inhibits the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 μM); inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 μM, respectively),,
Formal name: (2R,3S,4R,5R,6R,11S,13S,14R)-11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, methyl ester
Synonyms: NSC 70845|U 15167
Molecular weight: 787.8
CAS: 1404-15-5
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents
