A hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A)

Nodularin – 100 µg

Brand:
Cayman
CAS:
118399-22-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea.{14058,14059} Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena.{13247} It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 µM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.{14060}  

 

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SKU: 10007190 - 100 µg Category:

Description

A hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively

Formal name: cyclo[3S-amino-9S-methoxy-2S,6E,8S-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]

Synonyms: 

Molecular weight: 825

CAS: 118399-22-7

Purity: ≥95%

Formulation: A clear film

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins|Microcystins||Research Area|Toxicology|Environmental|Aquatic Systems

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