A coumarin glucoside with diverse biological activity; reduces LPS-induced increases in TNF-α

Nodakenin – 1 mg

Brand:
Cayman
CAS:
495-31-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nodakenin is a coumarin glucoside originally isolated from P. decursivum that has anti-inflammatory, neuroprotective, and neurogenic activities.{43146,43147,43148,43149,43150} It dose-dependently reduces LPS-induced increases in TNF-α, IL-6, and IL-1β mRNA expression and protein levels and NK-κB activity and translocation in RAW 264.7 macrophages when used at concentrations ranging from 25 to 100 µM.{43147} Nodakenin (5, 10, and 20 mg/kg) prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of chronic asthma induced by ovalbumin.{43148} It also decreases the levels of IL-4, IL-5, IL-13, as well as matrix metalloproteinase-2 (MMP-2) and MMP-9 in bronchoalveolar lavage fluid (BALF). Nodakenin increases proliferation of neural progenitor cells in the adult mouse hippocampal dentate gyrus, increases hippocampal protein levels of AKT and glycogen synthase kinase-3β (GSK-3β), and improves learning and memory in the passive avoidance test.{43150}  

 

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SKU: 25213 - 1 mg Category:

Description

A coumarin glucoside with diverse biological activity; reduces LPS-induced increases in TNF-α, IL-6, and IL-1β mRNA expression and protein levels and NK-κB activity and translocation in RAW 264.7 macrophages at 25-100 µM; prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of ovalbumin-induced chronic asthma at 5, 10, and 20 mg/kg; decreases protein levels of IL-4, IL-5, IL-13, MMP-2, and MMP-9 in BALF; increases proliferation of neural progenitor cells in the dentate gyrus and improves learning and memory in the passive avoidance test in mice

Formal name: (2R)-2-[1-(β-D-glucopyranosyloxy)-1-methylethyl]-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one

Synonyms: 

Molecular weight: 408.4

CAS: 495-31-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Coumarins||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Neuroscience

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