A ferrioxamine siderophore; chelates iron in a chrome azurol S assay (IC50 = 9.9 µM); inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 µM for both); cytotoxic to T47D

Nocardamine – 1 mg

Brand:
Cayman
CAS:
26605-16-3
Storage:
-20
UN-No:
Non-Hazardous - /

Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities.{53489,53490,53491,53492} It chelates iron in a chrome azurol S assay (IC50 = 9.9 µM).{53489} Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 µM for both), an effect that can be reversed by iron.{53490} It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 µM, respectively).{53491} Nocardamine also induces morphological changes in BM-N4 insect cells.{53492}  

 

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SKU: 28745 - 1 mg Category:

Description

A ferrioxamine siderophore; chelates iron in a chrome azurol S assay (IC50 = 9.9 µM); inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 µM for both); cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 µM, respectively); induces morphological changes in BM-N4 insect cells

Formal name: 1,12,23-trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone

Synonyms:  Desferrioxamine E|Proferrioxamine E

Molecular weight: 600.7

CAS: 26605-16-3

Purity: ≥70%

Formulation: A solid

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