A hybrid molecule of indomethacin and an NO donor which combines the anti-inflammatory properties of an NSAID with the gastrointestinal protective effects of NO

NO-Indomethacin – 5 mg

Brand:
Cayman
CAS:
301838-28-8
Storage:
-20
UN-No:
Non-Hazardous - /

NO-indomethacin is a hybrid molecule of indomethacin and a nitric oxide (NO) donor. This drug design combines the anti-inflammatory properties of a non-steroidal anti-inflammatory drug (NSAID) with the gastrointestinal protective effects of NO. Compounds of this class retain their anti-inflammatory and analgesic activity, but have reduced gastrointestinal and kidney toxicity compared to the NSAID alone.{7024} NO-indomethacin also enhances the cancer chemopreventative activity of indomethacin. NO-indomethacin exhibits an IC50 of 82 µM, compared to >1,000 µM for indomethacin alone, for the inhibition of pancreatic cancer cell (PaCa-2) growth after 24 hours in culture.{12245}  

 

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SKU: 10005705 - 5 mg Category:

Description

A hybrid molecule of indomethacin and an NO donor which combines the anti-inflammatory properties of an NSAID with the gastrointestinal protective effects of NO

Formal name: N-acetyl-D-cysteine-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, 4-(nitrooxy)butyl ester

Synonyms:  NCX 2121

Molecular weight: 620.1

CAS: 301838-28-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen

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