A selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH

N,N’-Dicyclohexylurea – 25 g

Brand:
Cayman
CAS:
2387-23-7
Storage:
-20
UN-No:
Non-Hazardous - /

Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). N,N’ Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively.{12627} At 10 µM, DCU blocks the hydrolysis of cis- and trans-EETs by rat red blood cells and porcine coronary endothelial cells as well as completely inhibits 14,(15)-EET-induced PPARα activation.{17909,12613,17908}  

 

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SKU: 10004971 - 25 g Category:

Description

A selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively; at 10 µM, blocks the hydrolysis of cis- and trans-EETs and completely inhibits 14,(15)-EET-induced PPAR activation

Formal name: N,N’-dicyclohexyl-urea

Synonyms:  DCU|NSC 17013

Molecular weight: 224.3

CAS: 2387-23-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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