A cell-permeable

NKY80 – 10 mg

Brand:
Cayman
CAS:
299442-43-6
Storage:
-20
UN-No:
Non-Hazardous - /

NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).{28956} It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.{28956}  

 

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Description

A cell-permeable, selective inhibitor of the adenylyl cyclase isoform AC5 (IC50s = 8.3 μM, 1.7 mM, and 132 µM for AC5, AC2, and AC3 in the presence of Gsα GTPγS-forskolin); tissue selective for adenylyl cyclase catalytic activity in heart and lung

Formal name: 2-amino-7-(2-furanyl)-7,9-dihydro-5(6H)-quinazolinone

Synonyms:  Adenylyl Cyclase Type V Inhibitor

Molecular weight: 229.2

CAS: 299442-43-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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