An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52

Nitidine (chloride) – 10 mg

Brand:
Cayman
CAS:
13063-04-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Nitidine is an alkaloid originally isolated from Z. nitidium that has antimalarial, anti-inflammatory, and anticancer activities.{48927,48928,48929,48930,48931} It is active against the F32 chloroquine-sensitive and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection with an ED50 value of 18.9 mg/kg per day.{48927} It decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells when used at a concentration of 5 µM.{48929} Nitidine (5 mg/kg) decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia.{48930} It inhibits proliferation of B16 melanoma, MCF-7 and Hs 578T breast, and DU145 and MPC3 prostate cancer cells with IC50 values ranging from 2.65 to 370 ng/ml.{48928} Nitidine (0.1-10 µM) induces apoptosis and decreases STAT3 phosphorylation in HSC-3 and HSC-4 oral cancer cells, as well as reduces tumor growth in an HSC-3 mouse xenograft model when administered at a dose of 10 mg/kg per day for 24 days.{48931}  

 

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Description

An alkaloid; active against the F32 chloroquine-sensitive (IC50 = 0.52 µM) and FcB1 and FcM2 chloroquine-resistant strains of P. falciparum (IC50s = 0.52, 0.8, and 0.49 µM, respectively) and reduces parasitemia in a mouse model of P. vinckei infection (ED50 = 18.9 mg/kg per day); decreases LPS-induced increases in TNF-α, IL-1β, and IL-6 levels and p65 nuclear translocation in RAW 264.7 cells at 5 µM; decreases serum levels of IL-10, TNF-α, and IL-6 and reduces mortality in a mouse model of LPS-induced endotoxemia; inhibits proliferation of various cancer cells (IC50s = 2.65-370 ng/ml); induces apoptosis and decreases STAT3 phosphorylation in HSC3 and HSC4 oral cancer cells from 0.1-10 µM and reduces tumor growth in an HSC3 mouse xenograft model at 10 mg/kg per day for 24 days

Formal name: 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium, monochloride

Synonyms:  NSC 146397

Molecular weight: 383.8

CAS: 13063-04-2

Purity: ≥98%

Formulation: A solid

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