A NET inhibitor (Ki = 5.1 nM); selective for NET over DAT and SERT (Kis = 477 and 383 nM

Nisoxetine (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
57754-86-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nisoxetine is a norepinephrine transporter (NET) inhibitor (Ki = 5.1 nM).{46723} It is selective for NET over the dopamine transporter (DAT) and the serotonin (5-HT) transporter (SERT; Kis = 477 and 383 nM, respectively). Nisoxetine inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release in mouse brain (EC50s = 2.97 and 0.08 µM, respectively).{46724} It reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine, in mice when administered at a dose of 32 mg/kg.{46725} Nisoxetine (0.5 mg/kg i.v.) also reduces cataplexy in narcoleptic dogs.{46726}  

 

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SKU: 29637 - 25 mg Category:

Description

A NET inhibitor (Ki = 5.1 nM); selective for NET over DAT and SERT (Kis = 477 and 383 nM, respectively); inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release in mouse brain (EC50s = 2.97 and 0.08 µM, respectively); reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine, in mice at 32 mg/kg; reduces cataplexy in narcoleptic dogs at 0.5 mg/kg i.v.

Formal name: γ-(2-methoxyphenoxy)-N-methyl-benzenepropanamine, monohydrochloride

Synonyms:  Lilly 94939|NSC 298819

Molecular weight: 307.8

CAS: 57754-86-6

Purity: ≥98%

Formulation: A crystalline solid

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