An inhibitor L-type CaV channels; selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM

Nimodipine – 500 mg

Brand:
Cayman
CAS:
66085-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nimodipine is an inhibitor of L-type voltage-gated calcium (CaV) channels.{28544} It is selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM.{28544,53840} Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips.{53841} It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53842}  

 

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Description

An inhibitor L-type CaV channels; selective for CaV1.2 over CaV1.3 channels (IC50s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Cav channels at 10 µM; inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips from 0.72-24 nM; increases cerebral blood flow in anesthetized dogs when administered sublingually from 0.01-1 mg/kg; decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by MCAO

Formal name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl) 5-(1-methylethyl) ester

Synonyms:  BAY-e 9736

Molecular weight: 418.4

CAS: 66085-59-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Neuroscience|Neuroprotection|Ischemia

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