An L-type calcium channel blocker; selective for L-type over N-

Nilvadipine – 5 mg

Brand:
Cayman
CAS:
75530-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nilvadipine is a dihydropyridine L-type calcium channel blocker.{28544} It is selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM. Nilvadipine (10 mg/kg per day, p.o.) inhibits increases in systolic blood pressure induced by chronic intravenous infusion of the peptide vasoconstrictor endothelin in rats.{53345} It decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease when administered at a dose of 0.03% (w/w) in the diet for 17 and 10 months, respectively.{53346} Nilvadipine (3.2 mg/kg, s.c.) reduces infarct volume in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).{53347}  

 

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Description

An L-type calcium channel blocker; selective for L-type over N-, P/Q-, and R-type calcium channels at 10 μM; inhibits increases in systolic blood pressure induced by chronic intravenous infusion of endothelin in rats at 10 mg/kg per day, p.o.; decreases cortical and hippocampal amyloid-β burden in the APPsw (Tg2576) and PS1/APPsw transgenic mouse models of Alzheimer’s disease at 0.03% (w/w) in the diet for 17 and 10 months, respectively; reduces infarct volume in a rat model of MCAO-induced focal cerebral ischemia at 3.2 mg/kg, s.c.

Formal name: 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-methyl 5-(1-methylethyl) ester

Synonyms:  (±)-Nilvadipine|CL 287,389|FK-235|FR34235|SKF 102362

Molecular weight: 385.4

CAS: 75530-68-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Signaling||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection|Ischemia

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