An inhibitor of PI5P4K (IC50 = ~1 µM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM); inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mpkCCD cells; an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM); increases accumulation of monoubiquitinated PCNA in H1299 NSCLC cells at 20 µM

NIH 12848 – 25 mg

Brand:
Cayman
CAS:
959551-10-1
Storage:
-20
UN-No:
Non-Hazardous - /

NIH 12848 is an inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ; IC50 = ~1 µM).{42606} It is selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM). NIH 12848 inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mouse principal kidney cortical collecting duct (mpkCCD) cells. NIH 12848 is also an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM).{42607} It increases accumulation of monoubiquitinated proliferating cell nuclear antigen (PCNA) in H1299 non-small cell lung cancer (NSCLC) cells when used at a concentration of 20 µM.  

 

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SKU: 26035 - 25 mg Category:

Description

An inhibitor of PI5P4K (IC50 = ~1 µM); selective for PI5P4Kγ over PI5P4Kα and PI5P4Kβ (IC50s = >100 µM); inhibits translocation of the Na+/K+-ATPase to the plasma membrane in mpkCCD cells; an inhibitor of USP1/UAF complex deubiquitinase activity (IC50 = 7.9 µM); increases accumulation of monoubiquitinated PCNA in H1299 NSCLC cells at 20 µM,

Formal name: N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-4-quinazolinamine

Synonyms: 

Molecular weight: 385.4

CAS: 959551-10-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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