Nifurtimox – 10 mg

Brand:
Cayman
CAS:
23256-30-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nifurtimox is an antiprotozoal agent.{41066} It is active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes with IC50 values of 9.91, 12.28, and 10.44 µM, respectively. Nifurtimox inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions.{41068} It reduces parasitemia and increases survival in a mouse model of T. cruzi infection when administered at doses of 10 and 40 mg/kg per day.{46634} Dietary administration of nifurtimox (150 mg/kg per day for 28 days) increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model.{46635}  

 

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Description

,An antiprotozoal agent; active against Taluahuén, LQ, and Brener strains of T. cruzi epimastigotes (IC50s = 9.91, 12.28, and 10.44 µM, respectively); inhibits clonogenic growth of HCT116, H838, C33A, LN18, KNS42, MDA-MB-231, and FaDu tumor cells under hypoxic conditions; reduces parasitemia and increases survival in a mouse model of T. cruzi infection at 10 and 40 mg/kg per day; dietary administration of nifurtimox increases tumor cell apoptosis and reduces tumor growth in an SMS-KCNR mouse xenograft model at 150 mg/kg per day for 28 days

Formal name: 3-methyl-N-[(5-nitro-2-furanyl)methylene]-4-thiomorpholinamine, 1,1-dioxide

Synonyms:  BAY-2502|BAY-A-2502

Molecular weight: 287.3

CAS: 23256-30-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Chagas Disease

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