A class III antiarrhythmic agent that blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM) and MATE1 (IC50 = 6.5 µM)

Nifekalant (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
130656-51-8
Storage:
-20
UN-No:
Non-Hazardous - /

Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.{32992} It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).{24505} Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).{32993}  

 

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Description

A class III antiarrhythmic agent that blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM) and MATE1 (IC50 = 6.5 µM)

Formal name: 6-[[2-[(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino]ethyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, monohydrochloride

Synonyms: 

Molecular weight: 441.9

CAS: 130656-51-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Heart|Arrhythmia

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