An internal standard for the quantification of nifedipine by GC- or LC-MS

Nifedipine-d6 – 500 µg

Brand:
Cayman
CAS:
1188266-14-9
Storage:
-20
UN-No:
Non-Hazardous - /

Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine (Item No. 11106) by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.{45013} Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.{45014} It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.{45015} Formulations containing nifedipine have been used in the treatment of hypertension and angina.  

 

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SKU: 25510 - 500 µg Category:

Description

An internal standard for the quantification of nifedipine by GC- or LC-MS

Formal name: 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-di(methyl-d3) ester

Synonyms: 

Molecular weight: 352.4

CAS: 1188266-14-9

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension

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