A riboside form of nicotinamide; a precursor of NAD+ and a source of vitamin B3; increases intracellular and mitochondrial NAD+ content in C2C12

Nicotinamide riboside – 25 mg

Brand:
Cayman
CAS:
1341-23-7
Storage:
-20
UN-No:
Non-Hazardous - /

Nicotinamide riboside is a riboside form of nicotinamide (Item No. 11127) that is found in trace amounts in yeast-containing and milk-derived products.{38460} It is a precursor of NAD+ (Item No. 16077) and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM.{38461} It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and 3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.{38462}  

 

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SKU: 23132 - 25 mg Category:

Description

A riboside form of nicotinamide; a precursor of NAD+ and a source of vitamin B3; increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM; decreases acetylation of FOXO1 and SOD2 but not tubulin; increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet when used at a dose of 400 mg/kg per day; increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease,

Formal name: 3-(aminocarbonyl)-1-β-D-ribofuranosyl-pyridinium

Synonyms: 

Molecular weight: 255.3

CAS: 1341-23-7

Purity: ≥95% Contains ~80% cyclodextrin as stabilizer

Formulation: A low melting semi-solid

Product Type|Biochemicals|Small Molecule Activators|Deacetylases||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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