An anthelmintic mitochondrial uncoupler; inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy; induces mitochondrial uncoupling

Niclosamide – 25 g

Brand:
Cayman
CAS:
50-65-7
Storage:
-20
UN-No:
Excepted Quantity - 3077 / 9

Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models.{29804,17472,27785} It inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling.{17472,18706} It completely inhibits phosphorylation of ribosomal S6 kinases (S6K) when used at a concentration of 3 µM.{17472} Niclosamide (1 µM) induces mitochondrial uncoupling, decreasing cellular ATP concentrations and increasing the ratio of ADP to ATP in HepG2 cells, and activates AMP-activated protein kinase (AMPK) in NIH3T3 cells.{27785} It also increases lipid oxidation by 5-fold in HepG2 cells. It prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice when administered at a dose of at 125 mg/kg per day.{27785} Niclosamide also inhibits proliferation and colony formation of DU145 prostate cancer cells, which have constitutively active STAT3 (IC50s = 0.7 and 0.1 µM, respectively).{18706}  

 

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SKU: 10649 - 25 g Category:

Description

An anthelmintic mitochondrial uncoupler; inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy; induces mitochondrial uncoupling, activates AMPK, and increases lipid peroxidation in vitro at 1 µM; prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice at 125 mg/kg per day; inhibits proliferation and colony formation of DU145 prostate cancer cells (IC50s = 0.7 and 0.1 µM, respectively)

Formal name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide

Synonyms:  NSC 178296

Molecular weight: 327.1

CAS: 50-65-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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