An OST inhibitor; binds to and stabilizes the STT3B catalytic subunit of OST in a CETSA; inhibits N-linked glycosylation in a reporter assay using D54 ER-LucT cells (IC50 = 1.1 µM); reduces glycosylation and membrane localization of EGFR in H3255 lung adenocarcinoma cells and inhibits proliferation of PC-9 and A549 NSCLC cells at 10 µM; inhibits dengue and Zika virus replication in HEK293 cells (EC50s = 0.85 and 2.2 µM

NGI 1 – 50 mg

Brand:
Cayman
CAS:
790702-57-7
Storage:
-20
UN-No:
Non-Hazardous - /

NGI 1 is an oligosaccharyltransferase (OST) inhibitor.{57264} It binds to and stabilizes the STT3B catalytic subunit of OST in a cellular thermal shift assay (CETSA) and inhibits N-linked glycosylation in a reporter assay using D54 ER-LucT cells (IC50 = 1.1 µM). NGI 1 (10 µM) reduces glycosylation and membrane localization of EGFR in H3255 lung adenocarcinoma cells and inhibits proliferation of PC-9 and A549 non-small cell lung cancer (NSCLC) cells. It inhibits dengue and Zika virus replication in HEK293 cells (EC50s = 0.85 and 2.2 µM, respectively).{57265} NGI 1 also reduces viral RNA in HEK293 cells infected with West Nile virus or yellow fever virus.  

 

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SKU: 31519 - 50 mg Category:

Description

An OST inhibitor; binds to and stabilizes the STT3B catalytic subunit of OST in a CETSA; inhibits N-linked glycosylation in a reporter assay using D54 ER-LucT cells (IC50 = 1.1 µM); reduces glycosylation and membrane localization of EGFR in H3255 lung adenocarcinoma cells and inhibits proliferation of PC-9 and A549 NSCLC cells at 10 µM; inhibits dengue and Zika virus replication in HEK293 cells (EC50s = 0.85 and 2.2 µM, respectively); reduces viral RNA in HEK293 cells infected with West Nile virus or yellow fever virus

Formal name: 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-benzamide

Synonyms:  N-linked Glycosylation Inhibitor 1

Molecular weight: 394.5

CAS: 790702-57-7

Purity: ≥98%

Formulation: A solid

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