A tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases

NG 52 – 5 mg

Brand:
Cayman
CAS:
212779-48-1
Storage:
-20
UN-No:
Non-Hazardous - /

NG 52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively).{6960} It is ineffective against the yeast kinases Kin28p, Srb10, and Cak1p. NG 52 is cell permeable and inhibits the growth of S. cerevisiae (GI50 = 30 µM).{6960} It is an analog of purvalanol A (Item No. 14579), a potent inhibitor of mammalian cyclin-dependent kinases.{6960}  

 

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Description

A tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p (IC50s = 7 and 2 µM, respectively); inhibits the growth of S. cerevisiae (GI50 = 30 µM)

Formal name: 2-​[[6-​[(3-​chlorophenyl)​amino]​-​9-​(1-​methylethyl)​-​9H-​purin-​2-​yl]​amino]​-ethanol

Synonyms:  Compound 52

Molecular weight: 346.8

CAS: 212779-48-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Cycle

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