Immunogen: Peptide from the C-terminal region of NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) NF-κB (p65) • Applications: IHC

NF-κB (p65) Rabbit Monoclonal Antibody (Clone RM273) – 100 µl

Brand:
Cayman
Storage:

NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) Rabbit Monoclonal Antibody (Clone RM273) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.  

 

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SKU: 32223 - 100 µl Category:

Description

Immunogen: Peptide from the C-terminal region of NF-κB (p65) • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) NF-κB (p65) • Applications: IHC, WB

Synonyms: Nuclear Factor NF-κB p65 Subunit|Transcription Factor p65

Immunogen: Peptide from the C-terminal region of NF-κB (p65)

Formulation: 100 µl of protein A-affinity purified monoclonal antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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