Immunogen: Peptide from the NF-κB (p65) NLS • Host: Rabbit • Species Reactivity: (+) Human

NF-κB (p65) NLS Polyclonal Antibody – 1 ea

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Cayman
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NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman’s NF-κB (p65) NLS Polyclonal Antibody can be used for immunocytochemistry (ICC), immunofluorescence (IF), immunohistochemistry (IHC), IHC-paraffin (IHC-P), and Western blot (WB) applications. The antibody recognizes the NLS region of NF-κB to detect NF-κB at 65 kDa from human samples. It also recognizes the NLS region of NF-κB from chimpanzee, cow, gorilla, horse, monkey, and mouse samples.  

 

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SKU: 13751 - 1 ea Category:

Description

Immunogen: Peptide from the NF-κB (p65) NLS • Host: Rabbit • Species Reactivity: (+) Human, chimpanzee, cow, gorilla, horse, monkey, mouse • Applications: ICC, IF, IHC, IHC-P, WB

Synonyms: NF-κB3|Nuclear Factor-κB (p65) Nuclear Localization Signal|Transcription Factor p65

Immunogen: Peptide from the NF-κB (p65) NLS

Formulation: 100 µg of peptide affinity-purified polyclonal antibody

Isotype: IgG

Applications: ICC, IF, IHC, IHC-P, WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunocytochemistry||Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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