Inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells

NF-κB Activation Inhibitor III – 25 mg

Brand:
Cayman
CAS:
380623-76-7
Storage:
-20
UN-No:
Non-Hazardous - /

Matrix metalloproteinase-9 (MMP-9), via activation by TNF-α, plays a key role in tumor invasion and metastasis. NF-κB activation inhibitor III is a compound that inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells.{30517} It has been used to disrupt NF-κB signaling in order to study the role of syndecans in mediating extracellular matrix integrity.{30518}  

 

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Description

Inhibits TNF-α-induced MMP-9 protein expression (maximal effect at 10 µM) by blocking NF-κB activity in HT1080 human fibrosarcoma cells

Formal name: 3-​chloro-​4-​nitro-​N-​(5-​nitro-​2-​thiazolyl)​-benzamide

Synonyms:  SM-7368

Molecular weight: 328.7

CAS: 380623-76-7

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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