A sesquiterpene with diverse biological activities; found in C. sativa; decreases SOD and catalase activity

Nerolidol – 25 g

Brand:
Cayman
CAS:
7212-44-4
Storage:
-20
UN-No:
Non-Hazardous - /

Nerolidol is a sesquiterpene found in a variety of plants, including C. sativa, that has diverse biological activities, including antioxidant, anthelmintic, antinociceptive, and anti-inflammatory properties.{36924,43357,36925,36926,36927} It decreases superoxide dismutase (SOD) and catalase activity, reduces glutathione (GSH) levels, and increases malondialdehyde (MDA) levels in the brain when administered at a dose of 50 mg/kg in a rat model of Parkinson’s disease induced by rotenone (Item No. 13995).{36925} It also inhibits rotenone-induced increases in IL-1β, IL-6, and TNF-α in rat brain. Nerolidol (100, 200, and 400 mg/kg) reduces worm burden and egg production in a mouse model of schistosomiasis.{36926} It also decreases acetic acid-induced writhing and formalin-induced licking time in mice, indicating antinociceptive activity, and reduced carrageenan-induced paw edema when administered at doses of 300 and 400 mg/kg.{36927} Formulations containing nerolidol have been used as fragrance ingredients.  

 

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SKU: 23182 - 25 g Category:

Description

A sesquiterpene with diverse biological activities; found in C. sativa; decreases SOD and catalase activity, reduces GSH levels, and increases MDA levels in the brain at 50 mg/kg in a rat model of Parkinson’s disease induced by rotenone; reduces worm burden and egg production in a mouse model of schistosomiasis at 100, 200, and 400 mg/kg; has antinociceptive and anti-inflammatory activity in mice at 300 and 400 mg/kg

Formal name: 3,7,11-trimethyl-1,6,10-dodecatrien-3-ol

Synonyms:  (±)-Nerolidol

Molecular weight: 222.4

CAS: 7212-44-4

Purity: ≥95%

Formulation: An oil

Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Schistosomiasis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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