A naphthol with diverse biological activities; inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 μM

Nepodin – 10 mg

Brand:
Cayman
CAS:
3785-24-8
Storage:
-20
UN-No:
- /

Nepodin is a naphthol that has been found in Rumex and has diverse biological activities.{47732,47734,47733,47735} It inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 μM, respectively).{47732} Nepodin inhibits C. albicans and S. aureus biofilm formation in a concentration-dependent manner when used at concentrations ranging from 1 to 10 μM.{47734} It is active against chloroquine-sensitive and -resistant P. falciparum strains (IC50s = 0.74 and 0.79 μg/ml for strains 3D7 and S20, respectively).{47733} Nepodin (250 mg/kg) suppresses parasitemia and increases survival time in a mouse model of P. berghei infection. It also increases skeletal muscle phosphorylation of AMPK, reduces serum and hepatic triglyceride and cholesterol levels, and improves insulin resistance in db/db diabetic mice.{47735}  

 

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Description

A naphthol with diverse biological activities; inhibits COX-1 and COX-2 in vitro (IC50s = 27.43 and 32.28 μM, respectively); inhibits C. albicans and S. aureus biofilm formation from 1-10 μM; active against chloroquine-sensitive and -resistant P. falciparum strains (IC50s = 0.74 and 0.79 μg/ml for strains 3D7 and S20, respectively); suppresses parasitemia and increases survival time in a mouse model of P. berghei infection at 250 mg/kg; increases skeletal muscle phosphorylation of AMPK, reduces serum and hepatic triglyceride and cholesterol levels, and improves insulin resistance in db/db diabetic mice

Formal name: 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-ethanone

Synonyms:  Musizin|NSC 365795

Molecular weight: 216.2

CAS: 3785-24-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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