(-)-Neplanocin A – 500 µg

Brand:
Cayman
CAS:
72877-50-0
Storage:
-20
UN-No:
Non-Hazardous - /

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (−)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM).{18488} It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity.{19250,19251,19249,18488} Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).{19251,18484}  

 

Available on backorder

SKU: 10584 - 500 µg Category:

Description

Potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM); has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity


Formal name: 5R-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol

Synonyms: 

Molecular weight: 263.3

CAS: 72877-50-0

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases