A prodrug of the NSAID amfenac; metabolized to amfenac following topical exposure to ex vivo rabbit cornea; inhibits PG synthase 1 (IC50 = 64.3 µM); inhibits PG synthesis ex vivo in isolated rabbit iris/ciliary body by 59.9-100% at a topical ocular dose of 50 µL of a 0.1% solution; reduces protein and PGE2 accumulation in a rabbit model of acute ocular inflammation when used topically at a concentration of 0.1% prior to paracentesis

Nepafenac – 100 mg

Brand:
Cayman
CAS:
78281-72-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Nepafenac is a prodrug of amfenac, a non-steroidal anti-inflammatory drug (NSAID) and COX-1 and -2 inhibitor.{36332} Nepafenac is metabolized to amfenac following topical exposure to ex vivo rabbit cornea.{36333} Nepafenac is an inhibitor of prostaglandin (PG) synthase 1 (IC50 = 64.3 µM) that inhibits the production of prostaglandins ex vivo in isolated rabbit iris/ciliary body by 59.9-100% at a topical ocular dose of 50 µL of a 0.1% solution. It also reduces protein and PGE2 (Item No. 14010) accumulation in a rabbit model of acute ocular inflammation when used topically at a concentration of 0.1% prior to paracentesis. Formulations containing nepafenac have been used in the treatment of pain and inflammation associated with cataract surgery.  

 

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SKU: 23700 - 100 mg Category:

Description

A prodrug of the NSAID amfenac; metabolized to amfenac following topical exposure to ex vivo rabbit cornea; inhibits PG synthase 1 (IC50 = 64.3 µM); inhibits PG synthesis ex vivo in isolated rabbit iris/ciliary body by 59.9-100% at a topical ocular dose of 50 µL of a 0.1% solution; reduces protein and PGE2 accumulation in a rabbit model of acute ocular inflammation when used topically at a concentration of 0.1% prior to paracentesis

Formal name: 2-amino-3-benzoyl-benzeneacetamide

Synonyms:  AHR 9434|AL 6515

Molecular weight: 254.3

CAS: 78281-72-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology||Research Area|Neuroscience|Pain Research

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