An alkaloid; inhibits LPS-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 100 µM; inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells at 50 µM; reduces the citric acid-induced cough reflex in conscious guinea pigs at 133 µmol/kg; inhibits pulmonary collagen deposition and fibrosis

Neotuberostemonine – 5 mg

Brand:
Cayman
CAS:
143120-46-1
Storage:
-20
UN-No:
Non-Hazardous - /

Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities.{55083,55084,55085} It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 µM.{55083} Neotuberostemonine (50 µM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells.{55084} It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 µmol/kg.{55085} Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.{55083}  

 

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Description

An alkaloid; inhibits LPS-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 100 µM; inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells at 50 µM; reduces the citric acid-induced cough reflex in conscious guinea pigs at 133 µmol/kg; inhibits pulmonary collagen deposition and fibrosis, as well as BALF monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis at 40 mg/kg

Formal name: (2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one

Synonyms:  (+)-Neotuberostemonine|Tuberostemonine LG

Molecular weight: 375.5

CAS: 143120-46-1

Purity: ≥95%

Formulation: A crystalline solid

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