A reversible AChE inhibitor (Kd = 260 μM); dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 µg

Neostigmine (methyl sulfate) – 1 g

Brand:
Cayman
CAS:
51-60-5
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM).{40760} In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively).{40761} Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block.{40762} Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.  

 

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SKU: 23501 - 1 g Category:

Description

A reversible AChE inhibitor (Kd = 260 μM); dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 µg, respectively); restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block (5 μg, i.p.)

Formal name: 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-benzenaminium, methyl sulfate

Synonyms:  NSC 93753

Molecular weight: 334.4

CAS: 51-60-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Neuroscience|Pain Research

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