A semisynthetic glycoside chalcone

Neohesperidin dihydrochalcone – 5 g

Brand:
Cayman
CAS:
20702-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

Neohesperidin dihydrochalcone (NHDC) is a semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin (Item No. 23028).{46476,46477} It scavenges 59.9, 66.7, 6.3, and 20% of 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805), ABTS (Item No. 27317), superoxide, and hydroxyl radicals, respectively, in cell-free assays when used at a concentration of 50 μM.{46478} NHDC (200 mg/kg per day) inhibits decreases in hepatic GSH levels and increases in serum aspartate aminotransferase (AST) and alanine transaminase (ALT) activity and hepatic levels of reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of acute liver injury induced by paraquat.{46477}  

 

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SKU: 28510 - 5 g Category:

Description

A semisynthetic glycoside chalcone, an artificial sweetener, and a derivative of neohesperidin; scavenges 59.9, 66.7, 6.3, and 20% of DPPH, ABTS, superoxide, and hydroxyl radicals, respectively, in cell-free assays at 50 μM; inhibits decreases in hepatic GSH levels and increases in serum AST and ALT activity and hepatic levels of ROS, TBARS, NF-κB, IL-6, IL-1β, and TNF-α in a mouse model of paraquat-induced acute liver at 200 mg/kg per day

Formal name: 1-[4-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-1-propanone

Synonyms:  NHDC

Molecular weight: 612.6

CAS: 20702-77-6

Purity: ≥98%

Formulation: A solid

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