A bacterial metabolite; an AR antagonist that inhibits binding of DHT to ARs (IC50 = 13 μM); inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM); is cytotoxic to A549

Neoaureothin – 2.5 mg

Brand:
Cayman
CAS:
59795-94-7
Storage:
-20
UN-No:
Non-Hazardous - /

Neoaureothin is a bacterial metabolite that has been found in Streptomyces.{49162} It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively).{49163} It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.{49164}  

 

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SKU: 28091 - 2.5 mg Category:

Description

A bacterial metabolite; an AR antagonist that inhibits binding of DHT to ARs (IC50 = 13 μM); inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM); is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively); has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml); increases survival of P. densiflora trees inoculated with B. xylophilus

Formal name: 2-methoxy-3,5-dimethyl-6-[(2R,4Z)-tetrahydro-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)-2,4,6-heptatrien-1-ylidene]-2-furanyl]-4H-pyran-4-one

Synonyms:  NSC 260179|Spectinabilin

Molecular weight: 477.6

CAS: 59795-94-7

Purity: ≥98%

Formulation: A solid

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